THE EFFECT OF BICYCLOL ON THE STATE OF THE CONNECTIVE TISSUE COMPONENTS OF THE LIVER EXTRACELLULAR MATRIX IN THE COMPLEX THERAPY OF NON-ALCOHOLIC STEATOHEPATITIS WITH LIVER FIBROSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

The aim of the research was to determine probable effect metformin, rosuvastatin and bicyclol on markers hepatocyte cytolysis in patients with nonalcoholic steatohepatitis diabetes mellitus type 2 diabetic kidney disease, degree steatosis stage liver fibrosis, as well content extracellular protein carbohydrate components blood tissues that are intensity fibrosis progression non-alcoholic steatohepatitis. Materials methods. Studу changes course treatment 60 I–IV disease conducted, among whom 48 were diagnosed mild 12 – moderate A comorbid i.e. severity, registered 100% steatohepatitis: them, 15 people had compensatory stage, 45 subcompensated stage. All including 21 cases I–II 20 III 19 IV disease. Results. Analysis results matrix connective tissue metabolism background indicated inflammatory dysmetabolic process contributed a significant imbalance components. In particular, activation anabolic collagen shown basis an increase protein-bound oxyproline by times (p < 0.05), decrease catabolism based free 1.4 which probably occurred due inhibition collagenolytic activity plasma (by times, p 0.05). That is, activated processes synthesis accompanied its degradation accumulation matrix. We also found hexosamines 1.5 0.05) accelerated carbohydrate-protein (with unbound fucose 2.6 0.05)). Conclusions. combination therapy Вicyclol individuals steatohepatitis, for 3 months helped eliminate syndrome hepatocytes, reduction optimization spectrum anabolism, increased total plasma, markers.